Journal article
Mutants of CHO cells resistant to the protein synthesis inhibitor emetine: Genetic and biochemical characterization of second-step mutants
Abstract
Second-step mutants highly resistant to the protein synthesis inhibitor emetine (EmtRII) have been selected from emetine resistant (EmtRI) Chinese hamster ovary cells described earlier. The frequency of the EmtRII mutants was increased 50- to 75-fold after mutagenesis, and none of these highly resistant mutants could be selected in one step using wild-type cells. Like the EmtRI mutants, the increased resistance of EmtRII mutants results from …
Authors
Gupta RS; Siminovitch L
Journal
Somatic Cell Genetics, Vol. 4, No. 1, pp. 77–94
Publisher
Springer Nature
Publication Date
January 1978
DOI
10.1007/bf01546494
ISSN
0098-0366