Journal article
Genetic and biochemical studies on mutants of CHO cells resistant to 7-deazapurine nucleosides: Differences in the mechanisms of action of toyocamycin and tubercidin
Abstract
From mutants of Chinese hamster ovary cells which are resistant to toyocamycin and tubercidin, second-step mutants which exhibit a further 8- to 9-fold increase in resistance to toyocamycin (ToyrII mutants) but no change in resistance to tubercidin have been isolated. The ToyrII mutants are similar to the first-step mutants in their levels of adenosine kinase activity (congruent to 1%), as well as cellular uptake and phosphorylation of …
Authors
Gupta RS; Mehta KD
Journal
Biochemical and Biophysical Research Communications, Vol. 120, No. 1, pp. 88–95
Publisher
Elsevier
Publication Date
April 1984
DOI
10.1016/0006-291x(84)91417-7
ISSN
0006-291X