Journal article
Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems
Abstract
The mutagenic effect of the antineoplastic drugs VP16 (etoposide; 4'-demethylepipodophyllotoxin-ethylidene-beta-D-glucopyranoside) and VM26 (teniposide; 4'-demethylepipodophyllotoxin-thenylidene-beta-D-glucopyr ano side) in mammalian and prokaryotic test systems have been compared. Both VP16 and VM26 which interact with mammalian DNA topoisomerase II, are strongly mutagenic in Chinese hamster ovary cells as indicated by the induction of …
Authors
Gupta RS; Bromke A; Bryant DW; Gupta R; Singh B; McCalla DR
Journal
Mutagenesis, Vol. 2, No. 3, pp. 179–186
Publisher
Oxford University Press (OUP)
Publication Date
1987
DOI
10.1093/mutage/2.3.179
ISSN
0267-8357