Journal article
Intrinsic multidrug resistance phenotype of chinese hamster (rodent) cells in comparison to human cells
Abstract
In comparison to human cells, cell lines of Chinese hamster and mouse origin exhibit between 10-50-fold resistance to a number of different drugs (viz. actinomycin D, daunomycin, chromomycin A3, colchicine, maytansine, mithramycin, puromycin, rhodamine 123, vinblastine and taxol). Studies with a representative Chinese hamster line (CHO) and a single-step multidrug resistant (MDR) mutant of human (HeLa) cells show that: (i) In comparison to the …
Authors
Gupta RS
Journal
Biochemical and Biophysical Research Communications, Vol. 153, No. 2, pp. 598–605
Publisher
Elsevier
Publication Date
6 1988
DOI
10.1016/s0006-291x(88)81137-9
ISSN
0006-291X