Journal article
Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors
Abstract
Immortalized SCN2.2 cells retain most biochemical and biophysical characteristics of the native rat SCN including the expression of clock genes and circadian regulatory proteins, and its distinctive pacemaker function. This study assessed the expression and signaling of MT(1) and MT(2) melatonin receptors in SCN2.2 cells. SCN2.2 cells express MT(1) and MT(2) receptors mRNA as detected by RT-PCR. In situ hybridization with digoxigenin-labeled …
Authors
Rivera-Bermúdez MA; Masana MI; Brown GM; Earnest DJ; Dubocovich ML
Journal
Brain Research, Vol. 1002, No. 1-2, pp. 21–27
Publisher
Elsevier
Publication Date
March 2004
DOI
10.1016/j.brainres.2003.12.008
ISSN
0006-8993