Fibrinogen Catabolism in Microangiopathic Haemolytic Anaemia Journal Articles

abstract

• Summary. Fibrinogen catabolism has been studied in six patients with microangiopathic haemolytic anaemia, three patients with fragmentary haemolytic anaemia following the insertion of valve prostheses into the heart and ten control patients. Increased rates of catabolism of 131 I‐fibrinogen were found in the patients with microangiopathic haemolytic anaemia. Evidence of enhanced fibrinolysis was not present.This finding suggests that intravascular coagulation is a feature of some cases of microangiopathic haemolytic anaemia and supports the hypothesis that the interaction of red cells with fibrin may result in the characteristic morphological appearances in these cases.

authors

• Baker, LRI
• Rubenberg, ML
• Dacie, JV
• Brain, Michael Cottrell

status

• published 

publication date

• June 1968

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• Adult (MeSH)
• Aged (MeSH)
• Anemia, Hemolytic (MeSH)
• Blood Cell Count (MeSH)
• Body Weight (MeSH)
• Erythrocyte Aggregation (MeSH)
• Female (MeSH)
• Fibrin (MeSH)
• Fibrinogen (MeSH)
• Fibrinolysis (MeSH)
• Hemoglobinometry (MeSH)
• Heparin (MeSH)
• Humans (MeSH)
• Immunology (Science Metrix)
• Iodine Isotopes (MeSH)
• Leukocyte Count (MeSH)
• Male (MeSH)
• Middle Aged (MeSH)
• Plasma (MeSH)
• Plasma Volume (MeSH)
• Urea (MeSH)

published in

• British Journal of Haematology  Journal

keywords

• Adult
• Aged
• Anemia, Hemolytic
• Blood Cell Count
• Body Weight
• Erythrocyte Aggregation
• Female
• Fibrin
• Fibrinogen
• Fibrinolysis
• Hemoglobinometry
• Heparin
• Humans
• Iodine Isotopes
• Leukocyte Count
• Male
• Middle Aged
• Plasma
• Plasma Volume
• Urea

Digital Object Identifier (DOI)

• 10.1111/j.1365-2141.1968.tb00368.x

PubMed ID

• 5657162

start page

• 617

end page

• 625

volume

• 14

issue

• 6