Journal article
Effect of Amiodarone and Sotalol on Ventricular Defibrillation Threshold
Abstract
BACKGROUND: Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial.
METHODS AND RESULTS: The Optimal Pharmacological Therapy in Cardioverter Defibrillator Patients (OPTIC) trial was a randomized clinical trial evaluating …
Authors
Hohnloser SH; Dorian P; Roberts R; Gent M; Israel CW; Fain E; Champagne J; Connolly SJ
Journal
Circulation, Vol. 114, No. 2, pp. 104–109
Publisher
Wolters Kluwer
Publication Date
July 11, 2006
DOI
10.1161/circulationaha.106.618421
ISSN
0009-7322
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenergic beta-AntagonistsAgedAmiodaroneAnti-Arrhythmia AgentsAtrial FibrillationBisoprololCarbazolesCarvedilolCombined Modality TherapyDefibrillators, ImplantableFemaleHeart ArrestHumansMaleMetoprololMiddle AgedMyocardial InfarctionPropanolaminesSotalolVentricular FibrillationVentricular Function, Left