Journal article
Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study
Abstract
BACKGROUND: Diagnosing pediatric pneumonia is challenging in low-resource settings. The World Health Organization (WHO) has defined primary end-point radiological pneumonia for use in epidemiological and vaccine studies. However, radiography requires expertise and is often inaccessible. We hypothesized that plasma biomarkers of inflammation and endothelial activation may be useful surrogates for end-point pneumonia, and may provide insight into …
Authors
Erdman LK; D’Acremont V; Hayford K; Rajwans N; Kilowoko M; Kyungu E; Hongoa P; Alamo L; Streiner DL; Genton B
Journal
PLOS ONE, Vol. 10, No. 9,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0137592
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdipokinesAntigens, CDBiomarkersC-Reactive ProteinCalcitoninCalcitonin Gene-Related PeptideChild, PreschoolChitinase-3-Like Protein 1Cohort StudiesEndoglinEnzyme-Linked Immunosorbent AssayFemaleFeverHumansInfantLectinsLikelihood FunctionsLogistic ModelsMalePneumoniaProtein PrecursorsROC CurveRadiographyReceptor, TIE-2Receptors, Cell SurfaceRegression AnalysisSensitivity and SpecificityTanzaniavon Willebrand Factor