Journal article
Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable.
Abstract
BACKGROUND: Adding clopidogrel to aspirin therapy reduces stroke in patients with atrial fibrillation (AF) but increases hemorrhage.
OBJECTIVE: To quantify the net benefit of adding clopidogrel to aspirin therapy, accounting for differences in clinical significance between ischemic and hemorrhagic events.
Authors
Connolly SJ; Eikelboom JW; Ng J; Hirsh J; Yusuf S; Pogue J; de Caterina R; Hohnloser S; Hart RG
Journal
Annals of Internal Medicine, Vol. 155, No. 9, pp. 579–586
Publisher
American College of Physicians
Publication Date
November 1, 2011
DOI
10.7326/0003-4819-155-9-201111010-00004
ISSN
1056-8751