Journal article
The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay
Abstract
1. The aim of this study was to assess the inhibitory activities of phosphodiesterase type 4 (PDE4) inhibitors on tumour necrosis factor-alpha (TNF-alpha) and leukotriene B4 (LTB4) production in a novel human whole blood assay. 2. Lipopolysaccharide (LPS) stimulation of human whole blood caused a time dependent increase in TNF-alpha and prostaglandin E2 (PGE2) plasma levels. Inhibition of LPS-induced TNF-alpha by the selective PDE4 inhibitor …
Authors
Brideau C; Van Staden C; Styhler A; Rodger IW; Chan C
Journal
British Journal of Pharmacology, Vol. 126, No. 4, pp. 979–988
Publisher
Wiley
Publication Date
February 1999
DOI
10.1038/sj.bjp.0702387
ISSN
0007-1188