Evaluation of a Soluble Fibrin Assay in Patients with Suspected Pulmonary Embolism Journal Articles

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abstract

SummaryIn order to determine the clinical utility of an enzyme immunoassay (EIA) for soluble fibrin in patients with suspected pulmonary embolism (PE), 195 unselected patients with suspected PE underwent blood sampling for measurement of plasma levels of soluble fibrin, and objective testing for PE. A soluble fibrin result of ≤ 0.75 Μg/ml showed a sensitivity of 100% for PE and a specificity of 12.8%, whereas a soluble fibrin result of ≤ 1.35 Μg/ml showed a sensitivity of 90.3% and a specificity of 49.4% for PE. The soluble fibrin assay has potential clinical utility in excluding PE.

authors

Ginsberg, Jeffrey S
Siragusa, Sergio
Douketis, James Demetrios
Johnston, Marilyn
Moffat, Karen
Donovan, Dianne
McGinnis, Joanne
Brill-Edwards, Patrick
Panju, Akbar
Patel, Ameen
Weitz, Jeffrey

status

published

publication date

1996

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
Adolescent (MeSH)
Adult (MeSH)
Aged (MeSH)
Aged, 80 and over (MeSH)
Cardiovascular System & Hematology (Science Metrix)
Evaluation Studies as Topic (MeSH)
Female (MeSH)
Fibrin (MeSH)
Humans (MeSH)
Immunoenzyme Techniques (MeSH)
Likelihood Functions (MeSH)
Male (MeSH)
Middle Aged (MeSH)
Predictive Value of Tests (MeSH)
Pulmonary Embolism (MeSH)
Reproducibility of Results (MeSH)
Retrospective Studies (MeSH)
Sensitivity and Specificity (MeSH)
Solubility (MeSH)

published in

Thrombosis and Haemostasis Journal