Journal article
An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells
Abstract
Type VI secretion (T6S) influences the composition of microbial communities by catalyzing the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S integral membrane toxin from Pseudomonas aeruginosa, Tse6, acts on target cells by degrading the universally essential dinucleotides NAD(+) and NADP(+). Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, …
Authors
Whitney JC; Quentin D; Sawai S; LeRoux M; Harding BN; Ledvina HE; Tran BQ; Robinson H; Goo YA; Goodlett DR
Journal
Cell, Vol. 163, No. 3, pp. 607–619
Publisher
Elsevier
Publication Date
10 2015
DOI
10.1016/j.cell.2015.09.027
ISSN
0092-8674