selected scholarly activity
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conferences
- An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. The FASEB Journal. 1-1. 2020
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journal articles
- A widespread accessory protein family diversifies the effector repertoire of the type VI secretion system spike.. Nature Communications. 15:10108. 2024
- The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins.. Journal of Biological Chemistry. 108007. 2024
- An enterococcal phage protein inhibits type IV restriction enzymes involved in antiphage defense. Nature Communications. 15:6955. 2024
- Structure of a tripartite protein complex that targets toxins to the type VII secretion system. Proceedings of the National Academy of Sciences of the United States of America. 121:e2312455121. 2024
- Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane. Nature Communications. 14:7808. 2023
- An enterococcal phage protein broadly inhibits type IV restriction enzymes involved in antiphage defense. bioRxiv. 4:2023.11.16.567456. 2023
- Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare. Journal of Bacteriology. 205:e0016123. 2023
- Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp. Proceedings of the National Academy of Sciences of the United States of America. 120:e2213771120. 2023
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Lack of evidence that Pseudomonas aeruginosa
AmpDh3‐PA0808 constitute a typeVI secretion system effector–immunity pair. Molecular Microbiology. 119:262-274. 2023 - Dual Targeting Factors Are Required for LXG Toxin Export by the Bacterial Type VIIb Secretion System. mBio. 13:e0213722. 2022
- An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs. Molecular Cell. 82:3484-3498.e11. 2022
- Structure of a bacterial Rhs effector exported by the type VI secretion system. PLoS Pathogens. 18:e1010182-e1010182. 2022
- Structure of a bacterial Rhs effector exported by the type VI secretion system 2021
- Dual role of a (p)ppGpp‐ and (p)ppApp‐degrading enzyme in biofilm formation and interbacterial antagonism. Molecular Microbiology. 115:1339-1356. 2021
- Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis. PLoS Pathogens. 17:e1009532-e1009532. 2021
- Structural Basis for Effector Transmembrane Domain Recognition by Type VI Secretion System Chaperones. The FASEB Journal. 35. 2021
- Bacterial type VII secretion: An important player in host‐microbe and microbe‐microbe interactions. Molecular Microbiology. 115:478-489. 2021
- Structure of the Extracellular Region of the Bacterial Type VIIb Secretion System Subunit EsaA. Structure. 29:177-185.e6. 2021
- Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones. eLife. 9:e62816. 2020
- Structure of the extracellular region of the bacterial type VIIb secretion system subunit EsaA 2020
- PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide–dependent biofilm formation. Journal of Biological Chemistry. 295:11949-11962. 2020
- Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines. Trends in Microbiology. 28:387-400. 2020
- Pel Polysaccharide Biosynthesis Requires an Inner Membrane Complex Comprised of PelD, PelE, PelF, and PelG. Journal of Bacteriology. 202:e00684-e00619. 2020
- An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature. 575:674-678. 2019
- The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology. Cell Reports. 29:187-201.e7. 2019
- The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton. Molecular Microbiology. 110:114-127. 2018
- Mechanism of loading and translocation of type VI secretion system effector Tse6. Nature Microbiology. 3:1142-1152. 2018
- Molecular Basis for Immunity Protein Recognition of a Type VII Secretion System Exported Antibacterial Toxin. Journal of Molecular Biology. 430:4344-4358. 2018
- Diverse NADase effector families mediate interbacterial antagonism via the type VI secretion system. Journal of Biological Chemistry. 293:1504-1514. 2018
- PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa. Journal of Biological Chemistry. 292:19411-19422. 2017
- A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. eLife. 6:e26938. 2017
- Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 114:2892-2897. 2017
- Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host and Microbe. 20:573-583. 2016
- Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Proceedings of the National Academy of Sciences of the United States of America. 113:3639-3644. 2016
- An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells. Cell. 163:607-619. 2015
- Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa. Journal of Biological Chemistry. 290:12451-12462. 2015
- Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa. eLife. 4. 2015
- A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism. Cell Host and Microbe. 16:227-236. 2014
- A conformational landscape for alginate secretion across the outer membrane ofPseudomonas aeruginosa. Acta Crystallographica Section D: Structural Biology. 70:2054-2068. 2014
- P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation. PLoS Pathogens. 10:e1004334-e1004334. 2014
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Genetically distinct pathways guide effector export through the type
VI secretion system. Molecular Microbiology. 92:529-542. 2014 - Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair. Journal of Biological Chemistry. 288:26616-26624. 2013
- PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa. Journal of Bacteriology. 195:2329-2339. 2013
- Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex. Journal of Biological Chemistry. 288:13356-13369. 2013
- Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria. Trends in Microbiology. 21:63-72. 2013
- The Structure- and Metal-dependent Activity of Escherichia coli PgaB Provides Insight into the Partial De-N-acetylation of Poly-β-1,6-N-acetyl-d-glucosamine. Journal of Biological Chemistry. 287:31126-31137. 2012
- The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix. Environmental Microbiology. 14:1913-1928. 2012
- Combiningin situproteolysis and mass spectrometry to crystallizeEscherichia coliPgaB. Acta Crystallographica Section F: Structural Biology Communications. 68:842-845. 2012
- Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa. Journal of Biological Chemistry. 287:23582-23593. 2012
- Expression, purification, crystallization and preliminary X-ray analysis ofPseudomonas aeruginosaPelD. Acta Crystallographica Section F: Structural Biology Communications. 68:181-184. 2012
- Re-Evaluation of a Bacterial Antifreeze Protein as an Adhesin with Ice-Binding Activity. PLoS ONE. 7:e48805-e48805. 2012
- Structural basis for alginate secretion across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 108:13083-13088. 2011
- AlgK Is a TPR-Containing Protein and the Periplasmic Component of a Novel Exopolysaccharide Secretin. Structure. 18:265-273. 2010
- Expression, refolding, crystallization and preliminary X-ray analysis ofPseudomonas aeruginosaAlgE. Acta Crystallographica Section F: Structural Biology Communications. 65:463-466. 2009
- ChemInform Abstract: Iron‐Catalyzed Cross‐Coupling Reactions Between a Bicyclic Alkenyl Triflates and Grignard Reagents.. ChemInform. 40:no-no. 2009
- Iron-Catalyzed Cross-Coupling Reactions between a Bicyclic Alkenyl Triflate and Grignard Reagents. Journal of Organic Chemistry. 73:7829-7832. 2008
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preprints
- Structure of a tripartite protein complex that targets toxins to the type VII secretion system 2023
- Dual targeting factors are required for LXG toxin export by the bacterial type VIIb secretion system 2022
- Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones 2020
- PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation 2020
- The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension