Evidence of astrogliosis in rat hippocampus after d-amphetamine exposure Journal Articles uri icon

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  • INTRODUCTION: Psychostimulants such as amphetamine (AMPH) induce manic-like symptoms in humans and studies have suggested that bipolar disorder (BD) may be associated to dopamine dysfunction. Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization. PURPOSE: We aimed to investigate the behavioral effects of acute and chronic AMPH on rat locomotion and assess GFAP levels in rat cortex and hippocampus. METHODS: Rats were administered either acute (single dose) or chronic (seven days) d-amphetamine IP injection. Locomotion was assessed with an open-field test and GFAP immunoquantity was measured using ELISA. RESULTS: Chronic, but not acute, administration of AMPH increased GFAP levels in rat hippocampus. No differences were observed in rat cortex. CONCLUSIONS: Repeated exposure to AMPH leads to an astroglial response in the hippocampus of rats.


  • Frey, Benicio
  • Andreazza, Ana C
  • Ceresér, Keila M
  • Martins, Márcio R
  • Petronilho, Fabrícia C
  • de Souza, Daniela F
  • Tramontina, Francine
  • Gonçalves, Carlos A
  • Quevedo, João
  • Kapczinski, Flavio

publication date

  • September 2006

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