Journal article
Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania
Abstract
BACKGROUND: Acute mania can be modeled in animals using D-amphetamine (AMPH). Acute AMPH injections are associated with monoamine depletion, loss of neurofilaments and neurite degeneration. However, the precise mechanisms underlying AMPH-induced neurotoxicity are still unclear. Several studies have demonstrated that oxidative stress may play a role in the behavioral and neurochemical changes observed after AMPH administration.
METHODS: The …
Authors
Frey BN; Martins MR; Petronilho FC; Dal‐Pizzol F; Quevedo J; Kapczinski F
Journal
Bipolar Disorders, Vol. 8, No. 3, pp. 275–280
Publisher
Wiley
Publication Date
June 2006
DOI
10.1111/j.1399-5618.2006.00318.x
ISSN
1398-5647