Journal article
Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania
Abstract
It has been demonstrated that lithium (Li) and valproate (VPT), first line mood stabilizers, increase BDNF content in rat hippocampus and frontal cortex, which suggests that the regulation of neurotrophic factors might be associated with their pharmacological effects. In sight of the scarcity of studies with other neurotrophins, and the possible relevance of multiple neurotrophic signaling systems in bipolar disorder we investigated the effects …
Authors
Walz JC; Frey BN; Andreazza AC; Ceresér KM; Cacilhas AA; Valvassori SS; Quevedo J; Kapczinski F
Journal
Journal of Psychiatric Research, Vol. 42, No. 5, pp. 416–421
Publisher
Elsevier
Publication Date
April 2008
DOI
10.1016/j.jpsychires.2007.03.005
ISSN
0022-3956