Journal article
Behavioral and neurochemical effects of sodium butyrate in an animal model of mania
Abstract
The present study investigated the effect of the histone deacetylase inhibitor, sodium butyrate (SB), on locomotor behavior and on mitochondrial respiratory-chain complexes activity in the brain of rats subjected to an animal model of mania induced by d-amphetamine (d-AMPH). In the reversal treatment, Wistar rats were first treated with d-AMPH or saline (Sal) for 14 days. Thereafter, between days 8 and 14, rats were administered SB or Sal. In …
Authors
Moretti M; Valvassori SS; Varela RB; Ferreira CL; Rochi N; Benedet J; Scaini G; Kapczinski F; Streck EL; Zugno AI
Journal
Behavioural Pharmacology, Vol. 22, No. 8, pp. 766–772
Publisher
Wolters Kluwer
Publication Date
12 2011
DOI
10.1097/fbp.0b013e32834d0f1b
ISSN
0955-8810