Journal article
Imipramine treatment reverses depressive‐like behavior in alloxan‐diabetic rats
Abstract
BACKGROUND: A growing body of evidence has shown an association between diabetes and depression, as well a role of brain-derived neurotrophic factor (BDNF) in diabetes and depression. The present study was designed to evaluate the behavioural and molecular effects of the anti-depressant imipramine in diabetic rats.
METHODS: To this aim, after induction of diabetes by alloxan (150 mg/kg), Wistar rats were treated with imipramine (30 mg/kg) once …
Authors
Ceretta LB; Réus GZ; Stringari RB; Ribeiro KF; Zappellini G; Aguiar BW; Pfaffenseller B; Lersh C; Kapczinski F; Quevedo J
Journal
Diabetes/Metabolism Research and Reviews, Vol. 28, No. 2, pp. 139–144
Publisher
Wiley
Publication Date
February 2012
DOI
10.1002/dmrr.1285
ISSN
1520-7552