Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder Academic Article uri icon

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  • Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis of psychiatric disordersand is related to traumatic life events. To examine serum BDNF levels, we compared one group of DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF levels were significantly decreased in GID patients (p = 0.013). This data support the hypothesis that the reduction found in serum BDNF levels in GID patients may be related to the psychological abuse that transsexuals are exposed during their life.


  • Fontanari, Anna-Martha V
  • Andreazza, Tahiana
  • Costa, Ângelo B
  • Salvador, Jaqueline
  • Koff, Walter J
  • Aguiar, Bianca
  • Ferrari, Pamela
  • Massuda, Raffael
  • Pedrini, Mariana
  • Silveira, Esalba
  • Belmonte-de-Abreu, Paulo S
  • Gama, Clarissa S
  • Kauer-Sant'Anna, Marcia
  • Kapczinski, Flavio
  • Lobato, Maria Ines R

publication date

  • October 2013