Journal article
Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania
Abstract
Several studies have suggested that alterations in brain-derived neurotrophic factor (BDNF) and increased oxidative stress have a central role in bipolar disorder (BD). Intracerebroventricular (ICV) injection of ouabain (OUA) in rats alters oxidative stress parameters and decreases BDNF levels in the brain. In this context, the present study aims to investigate the effects of BDNF ICV administration on BDNF levels and oxidative stress …
Authors
Valvassori SS; Arent CO; Steckert AV; Varela RB; Jornada LK; Tonin PT; Budni J; Mariot E; Kapczinski F; Quevedo J
Journal
Molecular Neurobiology, Vol. 52, No. 1, pp. 353–362
Publisher
Springer Nature
Publication Date
August 2015
DOI
10.1007/s12035-014-8873-8
ISSN
0893-7648