Journal article
Effects of sodium butyrate on aversive memory in rats submitted to sepsis
Abstract
Epigenetic mechanisms are involved in normal behavior and are implicated in several brain neurodegenerative conditions, psychiatric and inflammatory diseases as well. Moreover, it has been demonstrated that sepsis lead to an imbalance in acetylation of histones and that histone deacetylase inhibitors (HDACi) can reverse this condition. In the present study, we evaluated the effects of a microinjection of sodium butyrate (SB, HDACi) into …
Authors
Steckert AV; Comim CM; Igna DMD; Dominguini D; Mendonça BP; Ornell F; Colpo GD; Gubert C; Kapczinski F; Barichello T
Journal
Neuroscience Letters, Vol. 595, , pp. 134–138
Publisher
Elsevier
Publication Date
5 2015
DOI
10.1016/j.neulet.2015.04.019
ISSN
0304-3940