Metabolic syndrome in subjects with bipolar disorder and major depressive disorder in a current depressive episode: Population-based study Academic Article uri icon

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  • OBJECTIVE: To assess the differences in the prevalence of the metabolic syndrome (MetS) and their components in young adults with bipolar disorder (BD) and major depressive disorder (MDD) in a current depressive episode. METHODS: This was a cross-sectional study with young adults aged 24-30 years old. Depressive episode (bipolar or unipolar) was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). RESULTS: The sample included 972 subjects with a mean age of 25.81 (±2.17) years. Both BD and MDD patients showed higher prevalence of MetS compared to the population sample (BD = 46.9%, MDD = 35.1%, population = 22.1%, p < 0.001). Higher levels of glucose, total cholesterol and LDL cholesterol, Body Mass Index, low levels of HDL cholesterol, and a higher prevalence of abdominal obesity were observed in both BD and MDD individuals with current depressive episode compared to the general population. Moreover, there was a significant difference on BMI values in the case of BD and MDD subjects (p = 0.016). CONCLUSION: Metabolic components were significantly associated with the presence of depressive symptoms, independently of the diagnosis.


  • Moreira, Fernanda Pedrotti
  • Jansen, Karen
  • Cardoso, Taiane de Azevedo
  • Mondin, Thaíse Campos
  • Magalhães, Pedro Vieira da Silva
  • Kapczinski, Flavio
  • Souza, Luciano Dias de Mattos
  • da Silva, Ricardo Azevedo
  • Oses, Jean Pierre
  • Wiener, Carolina David

publication date

  • September 2017