Journal article
Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial
Abstract
Aims/objectiveConflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.MethodsA large multicentre …
Authors
The TIDE Trial Investigators
Journal
Diabetologia, Vol. 55, No. 1, pp. 36–45
Publisher
Springer Nature
Publication Date
1 2012
DOI
10.1007/s00125-011-2357-4
ISSN
0012-186X
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AgedCardiovascular DiseasesCholecalciferolCombined Modality TherapyDiabetes Mellitus, Type 2Dietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodEarly Termination of Clinical TrialsFemaleHumansHypoglycemic AgentsIncidenceMaleMiddle AgedNeoplasmsPioglitazoneRisk FactorsRosiglitazoneThiazolidinediones