An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts

AbstractThis study investigates the effect of well‐defined poly(dimethylsiloxane)–poly(ethylene glycol) (PDMS–PEG) ABA linear block co‐oligomers on the proliferation of human dermal fibroblasts. The co‐oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic–lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co‐oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down‐regulation of fibroblast proliferation, and the ratio HLB/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures with highest efficiency to be determined. These results suggest the possible use of the PEG–PDMS–PEG block co‐oligomers as an alternative to silicone gels for hypertrophic scar remediation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.

An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts Journal Articles