Journal article
ERG K+ currents regulate pacemaker activity in ICC
Abstract
Ether-à-go-go-related gene (ERG) K channels have been implicated in the generation of pacemaker activities in the heart. To study the presence and function of ERG K channels in the pacemaker cells of the small intestine [the interstitial cells of Cajal (ICC)], a combination of patch-clamp techniques, tissue and live cell immunohistochemistry, RT-PCR, and in vitro functional studies were performed. Nonenzymatically isolated ICC in culture were …
Authors
Zhu Y; Golden CM; Ye J; Wang X-Y; Akbarali HI; Huizinga JD
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 285, No. 6, pp. g1249–g1258
Publisher
American Physiological Society
Publication Date
December 2003
DOI
10.1152/ajpgi.00149.2003
ISSN
0193-1857
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnimals, NewbornBiological ClocksCation Transport ProteinsCells, CulturedDNA-Binding ProteinsERG1 Potassium ChannelElectric ConductivityEther-A-Go-Go Potassium ChannelsHumansImmunohistochemistryIntestine, SmallMiceMice, Inbred StrainsPiperidinesPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedPyridinesTetraethylammoniumTrans-ActivatorsTranscriptional Regulator ERG