Limited Protective Effect of the CCR5Δ32/CCR5Δ32 Genotype on Human Immunodeficiency Virus Infection Incidence in a Cohort of Patients with Hemophilia and Selection for Genotypic X4 Virus Academic Article uri icon

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abstract

  • The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in approximately 2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.

authors

  • Iversen, Astrid KN
  • Christiansen, Claus Bohn
  • Attermann, Jørn
  • Eugen‐Olsen, Jesper
  • Schulman, Sam
  • Berntorp, Erik
  • Ingerslev, Jørgen
  • Fugger, Lars
  • Scheibel, Elma
  • Tengborn, Lillian
  • Gerstoft, Jan
  • Dickmeiss, Ebbe
  • Svejgaard, Arne
  • Skinhøj, Peter

publication date

  • January 15, 2003

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