Journal article
The in vivo delivery of heterologous proteins by microencapsulated recombinant cells
Abstract
The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.
Authors
Chang PL; Van Raamsdonk JM; Hortelano G; Barsoum SC; MacDonald NC; Stockley TL
Journal
Trends in Biotechnology, Vol. 17, No. 2, pp. 78–83
Publisher
Elsevier
Publication Date
February 1, 1999
DOI
10.1016/s0167-7799(98)01250-5
ISSN
0167-7799