selected scholarly activity
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books
- Somatic gene therapy 2018
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chapters
- Somatic Gene Therapy. 203-224. 2018
- Artificial cells as a novel approach to gene therapy. 236-291. 2007
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conferences
- 1085. In Vivo Imaging of Microencapsulated Gene Therapy. Molecular Therapy. S416-S416. 2006
- Combined immunotherapy and anti-angiogenic therapy of cancer delivered by genetically engineered non-autologous microencapsulated cells. Molecular Therapy. S16-S16. 2003
- MRI-visible microcapsules for gene therapy. Molecular Therapy. S325-S325. 2003
- Encapsulation for Somatic Gene Therapy. Annals of the New York Academy of Sciences. 146-158. 1999
- Microcapsules as Bio‐organs for Somatic Gene Therapya. Annals of the New York Academy of Sciences. 461-473. 1997
- Non‐Autologous Transplantation with Immuno‐isolation in Large Animals—A Review. Annals of the New York Academy of Sciences. 408-426. 1997
- Use of immunosuppressive agents in gene therapy for prolonged delivery of recombinant products.. American Journal of Human Genetics. A358-A358. 1997
- Gene therapy for murine mucopolysaccharidosis type VII. Neuromuscular Disorders. 352-360. 1997
- Arylsulfatase A pseudodeficiency and the dopamine receptor D4 polymorphism: Genetic risk factors for psychiatric disorders in Caucasians.. Clinical Chemistry. 431-431. 1996
- Microencapsulation — An alternative approach to gene therapy. Transfusion and Apheresis Science. 35-43. 1996
- APPLICATION OF IMMUNOISOLATION TO SOMATIC GENE-THERAPY. Journal of Cellular Biochemistry. 7-7. 1995
- DELIVERY OF FACTOR-IX IN MICE FROM IMPLANTABLE MICROCAPSULES AS A MODEL FOR GENE-THERAPY OF HEMOPHILIA-B. Journal of Cellular Biochemistry. 365-365. 1995
- ALLOGENEIC SOMATIC GENE-THERAPY - CORRECTION OF GROWTH-HORMONE DEFICIENCY IN DWARF MICE WITH MICRO-ENCAPSULATED NON-AUTOLOGOUS MYOBLASTS. American Journal of Human Genetics. 107-107. 1993
- EFFECT OF BONE-MARROW TRANSPLANT OF THE BEHAVIORAL ABNORMALITIES OF A MURINE MODEL OF MUCOPOLYSACCHARIDOSIS TYPE-VII (SLY DISEASE). American Journal of Human Genetics. 912-912. 1993
- DELIVERY OF A NOVEL GENE-PRODUCT THROUGH MICRO-ENCAPSULATED NON-AUTOLOGOUS CELLS. American Journal of Human Genetics. 435-435. 1991
- SECRETION OF HUMAN FACTOR-IX THROUGH MICRO-ENCAPSULATED RECOMBINANT FIBROBLASTS. American Journal of Human Genetics. 437-437. 1991
- ISOZYMES OF ARYLSULFATASE-C (ARC) - BIOCHEMICAL-PROPERTIES. Pediatric Research. A272-A272. 1986
- INACTIVATION PROPERTIES AT THE ARYLSULFATASE-C LOCUS. American Journal of Human Genetics. A172-A172. 1982
- PSEUDO ARYLSULFATASE-A DEFICIENCY DISORDER - A GENETIC AND BIOCHEMICAL EXPLANATION. American Journal of Human Genetics. A48-A48. 1982
- ARYLSULFATASE-C ISOZYMES IN HUMAN-TISSUES. American Journal of Human Genetics. A38-A38. 1981
- HISTOCHEMICAL STAINING FOR ARYLSULFATASE-A ACTIVITY IN CULTURED HUMAN-FIBROBLASTS. Journal of Cell Biology. A247-A247. 1981
- A TEST OF ALLELISM IN CLINICAL VARIANTS OF INHERITED DISEASES. Canadian Journal of Neurological Sciences. 115-115. 1980
- COMPLEMENTATION STUDIES OF ARYLSULFUTASE-A (AS-A) IN HYBRID-CELLS FROM PATIENTS WITH METACHROMATIC LEUKO-DYSTROPHY (MLD) AND MULTIPLE SULFATASE DEFICIENCY DISORDER (MSDD). Pediatric Research. 520-520. 1980
- USE OF SOMATIC-CELL HYBRIDS ISOLATED BY A NEW TECHNIQUE TO STUDY COMPLEMENTATION OF ARYL-SULFATASE-A (ASA) IN METACHROMATIC LEUKODYSTROPHY (MLD) AND MULTIPLE SULFATASE DEFICIENCY DISORDER (MSDD). European Journal of Cell Biology. 597-597. 1980
- COMPLEMENTATION OF ARYLSULFATASE-A IN SOMATIC-CELL HYBRIDS FORMED BY FUSION BETWEEN FIBROBLASTS FROM PATIENTS WITH METACHROMATIC LEUKODYSTROPHY AND MULTIPLE SULFATASE DEFICIENT DISORDER. American Journal of Human Genetics. A42-A42. 1979
- RESIDUAL ARYLSULFATASE-A ACTIVITY IN FIBROBLASTS FROM PATIENTS WITH METACHROMATIC LEUKODYSTROPHY. American Journal of Human Genetics. A24-A24. 1978
- NEW METHOD FOR NON-SELECTIVE ISOLATION OF HYBRIDS BETWEEN HUMAN DIPLOID FIBROBLASTS. American Journal of Human Genetics. A30-A30. 1977
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journal articles
- Isolation of human foetal myoblasts and its application for microencapsulation. Journal of Cellular and Molecular Medicine. 12:271-280. 2008
- Enhancement of myoblast microencapsulation for gene therapy. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 77B:296-306. 2006
- Immuno-Isolation in Cancer Gene Therapy. Current Gene Therapy. 6:181-191. 2006
- Biological properties of photocrosslinked alginate microcapsules. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 75B:425-434. 2005
- Encapsulation of Recombinant Cells with a Novel Magnetized Alginate for Magnetic Resonance Imaging. Human gene therapy. Clinical development. 16:971-984. 2005
- A multiprong approach to cancer gene therapy by coencapsulated cells. Cancer Gene Therapy. 12:369-380. 2005
- A novel method to enhance the stability of alginate-poly-L-lysine-alginate microcapsules. Journal of Biomaterials Science, Polymer Edition. 16:89-111. 2005
- Quantitative chemical mapping of sodium acrylate- and N-vinylpyrrolidone-enhanced alginate microcapsules. Journal of Biomaterials Science, Polymer Edition. 16:611-627. 2005
- Combined Immunotherapy and Antiangiogenic Therapy of Cancer with Microencapsulated Cells. Human gene therapy. Clinical development. 15:945-959. 2004
- Delivery of recombinant gene product to canine brain with the use of microencapsulation. Translational Research. 142:399-413. 2003
- Properties of a novel magnetized alginate for magnetic resonance imaging. Biotechnology and Bioengineering. 83:282-292. 2003
- Antiangiogenic Cancer Therapy with Microencapsulated Cells. Human gene therapy. Clinical development. 14:1065-1077. 2003
- Effect of growth factors and extracellular matrix materials on the proliferation and differentiation of microencapsulated myoblasts. Journal of Biomaterials Science, Polymer Edition. 14:533-549. 2003
- A Novel Approach to Tumor Suppression with Microencapsulated Recombinant Cells. Human gene therapy. Clinical development. 13:1157-1166. 2002
- Deterioration of polyamino acid-coated alginate microcapsules in vivo. Journal of Biomaterials Science, Polymer Edition. 13:863-884. 2002
- Development of small alginate microcapsules for recombinant gene product delivery to the rodent brain. Journal of Biomaterials Science, Polymer Edition. 13:953-962. 2002
- Treatment of hemophilia B in mice with nonautologous somatic gene therapeutics. Translational Research. 139:35-42. 2002
- Gene therapy for hemophilia B. International Journal of Pediatric Hematology/Oncology. 7:347-358. 2001
- Immuno-Isolation in Oncology - A Mini-Review. Current Pharmaceutical Biotechnology. 2:269-277. 2001
- Cell adhesion peptide modification of gold-coated polyurethanes for vascular endothelial cell adhesion. Journal of applied biomaterials. 54:272-283. 2001
- Osmotic pressure test: A simple, quantitative method to assess the mechanical stability of alginate microcapsules. Journal of applied biomaterials. 54:264-271. 2001
- Somatic Gene Therapy for a Neurodegenerative Disease Using Microencapsulated Recombinant Cells. Experimental Neurology. 166:276-286. 2000
- Treatment of a Lysosomal Storage Disease, Mucopolysaccharidosis VII, with Microencapsulated Recombinant Cells. Human gene therapy. Clinical development. 11:2117-2127. 2000
- Canine models for human genetic neurodegenerative diseases. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 24:811-823. 2000
- Delivery of recombinant product from subcutaneous implants of encapsulated recombinant cells in canines. Translational Research. 135:484-492. 2000
- Gene Therapy for Hemophilia. Artificial Cells, Nanomedicine and Biotechnology. 28:1-24. 2000
- Review‐The Use of Immunosuppressive Agents to Prevent Neutralizing Antibodies Against a Transgene Product. Annals of the New York Academy of Sciences. 875:159-174. 1999
- Persistent Delivery of Factor IX in Mice: Gene Therapy for Hemophilia Using Implantable Microcapsules. Human gene therapy. Clinical development. 10:1281-1288. 1999
- The in vivo delivery of heterologous proteins by microencapsulated recombinant cells. Trends in Biotechnology. 17:78-83. 1999
- Delivery of Recombinant Gene Products to the Central Nervous System with Nonautologous Cells in Alginate Microcapsules. Human gene therapy. Clinical development. 10:49-59. 1999
- Encapsulation of various recombinant mammalian cell types in different alginate microcapsules. Journal of applied biomaterials. 42:587-596. 1998
- Gene therapy in pediatrics. Drugs of Today. 34:759-759. 1998
- Development of engineered cells for implantation in gene therapy. Advanced Drug Delivery Reviews. 33:31-43. 1998
- Suppression of Immunological Response Against a Transgene Product Delivered from Microencapsulated Cells. Human gene therapy. Clinical development. 9:1275-1282. 1998
- Delivery of Recombinant Gene Product to Canines with Nonautologous Microencapsulated Cells. Human gene therapy. Clinical development. 9:195-206. 1998
- Evolutionary origins of two tightly linked mutations in arylsulfatase-A pseudodeficiency. Human Genetics. 101:135-140. 1997
- Nonautologous somatic gene therapy: A novel approach to drug delivery. Drug News and Perspectives. 10:331-340. 1997
- Nonautologous gene therapy with implantable devices. IEEE Pulse. 16:145-150, 161. 1997
- Permeability of alginate microcapsules to secretory recombinant gene products. Biotechnology and Bioengineering. 52:472-484. 1996
- Secretion of recombinant proteins from hydroxyethyl methacrylate-methyl methacrylate capsules. Biotechnology and Bioengineering. 51:271-280. 1996
- Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B. Blood. 87:5095-5103. 1996
- Somatic gene therapy. Cellular and Molecular Life Sciences. 52:A9-A10. 1996
- Growth Retardation—An Unexpected Outcome from Growth Hormone Gene Therapy in Normal Mice with Microencapsulated Myoblasts. Human gene therapy. Clinical development. 7:61-70. 1996
- Correction of the Growth Defect in Dwarf Mice with Nonautologous Microencapsulated Myoblasts—An Alternate Approach to Somatic Gene Therapy. Human gene therapy. Clinical development. 6:165-175. 1995
- Delivery of a Secretable Adenosine Deaminase Through Microcapsules–A Novel Approach to Somatic Gene Therapy. Human gene therapy. Clinical development. 5:1445-1455. 1994
- Behavioral consequences of bone marrow transplantation in the treatment of murine mucopolysaccharidosis type VII.. Journal of Clinical Investigation. 94:1180-1186. 1994
- Attitudes of high school students toward carrier screening and prenatal diagnosis of cystic fibrosis. Journal of Genetic Counseling. 3:141-155. 1994
- Growth of recombinant fibroblasts in alginate microcapsules. Biotechnology and Bioengineering. 43:925-933. 1994
- Delivery of Recombinant Gene Products with Microencapsulated Cells In Vivo. Human gene therapy. Clinical development. 4:433-440. 1993
- Metachromatic leukodystrophy: Multiple nonfunctional and pseudodeficiency alleles in a pedigree: Problems with diagnosis and counseling. Annals of Neurology. 34:212-218. 1993
- Expression of Human Factor IX by Microencapsulated Recombinant Fibroblasts. Human gene therapy. Clinical development. 4:291-301. 1993
- Behavioural abnormalities in a murine model of a human lysosomal storage disease. NeuroReport. 4:507-510. 1993
- Complications in the genotypic molecular diagnosis of pseudo arylsulfatase A deficiency. American Journal of Medical Genetics, Part A. 45:631-637. 1993
- Diagnosis of arylsulfatase A deficiency. American Journal of Medical Genetics, Part A. 43:976-982. 1992
- Intrathymic implants of genetically modified fibroblasts. The FASEB Journal. 6:2853-2858. 1992
- Molecular diagnosis of phenylketonuria. Journal of the International Federation of Clinical Chemistry. 3:58-65. 1991
- Expression of a novel gene product by transplants of genetically modified primary fibroblasts in the central nervous system. Journal of Neuroscience Research. 29:292-298. 1991
- Characterization of arylsulfatase C isozymes from human liver and placenta. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1078:251-257. 1991
- Growth inhibition by cyclosporine a and. Life Sciences. 48:1455-1461. 1991
- Autologous fibroblast implantation. Feasibility and potential problems in gene replacement therapy.. Molecular biology & medicine. 7:461-470. 1990
- Suppression of immunological response against a novel gene product delivered by implants of genetically modified fibroblasts.. Molecular biology & medicine. 7:471-477. 1990
- Intracellular distribution of DNA internalized through calcium phosphate precipitation. Experimental Cell Research. 190:170-174. 1990
- Energy dependence of DNA-mediated gene transfer and expression. Somatic Cell and Molecular Genetics. 16:305-310. 1990
- Hunter disease (mucopolysaccharidosis type II) in a karyotypically normal girl. Clinical Genetics. 37:355-362. 1990
- The human arylsulfatase-C isoenzymes: two distinct genes that escape from X inactivation.. American Journal of Human Genetics. 46:729-737. 1990
- Deficient glycosylation of arylsulfatase A in pseudo arylsulfatase-A deficiency. Molecular and Cellular Biochemistry. 92:117-127. 1990
- Heterogeneity of lysosomes in human fibroblasts. Molecular and Cellular Biochemistry. 87:171-183. 1989
- Marked clinical difference between two sibs affected with juvenile metachromatic leukodystrophy. American Journal of Medical Genetics, Part A. 33:10-13. 1989
- Presence of a lysosomal enzyme, arylsulfatase-A, in the prelysosome-endosome compartments of human cultured fibroblasts.. European Journal of Cell Biology. 48:71-78. 1989
- Effect of ammonium chloride on subcellular distribution of lysosomal enzymes in human fibroblasts. Experimental Cell Research. 176:258-267. 1988
- Pseudo arylsulfatase A deficiency Biosynthesis of an abnormal arylsulfatase A. FEBS Letters. 219:130-134. 1987
- Somatic cell hybridization of Roberts syndrome and normal human fibroblasts transfected with plasmids carrying dominant selection markers. Somatic Cell and Molecular Genetics. 13:245-252. 1987
- Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase.. American Journal of Human Genetics. 40:102-114. 1987
- Transformation of human cultured fibroblasts with plasmids carrying dominant selection markers and immortalizing potential. Experimental Cell Research. 167:407-416. 1986
- ASSOCIATION OF STEROID SULFATASE WITH ONE OF THE ARYLSULFATASE-C ISOZYMES IN HUMAN-FIBROBLASTS. Journal of Biological Chemistry. 261:4443-4447. 1986
- Association of steroid sulfatase with one of the arylsulfatase C isozymes in human fibroblasts.. Journal of Biological Chemistry. 261:14443-14447. 1986
- Biochemical characterization of arylsulfatase-C isozymes in human fibroblasts. Biochemical and Biophysical Research Communications. 128:1388-1394. 1985
- Action of surface-active agents on arylsulfatase-C of human cultured fibroblasts. Analytical Biochemistry. 144:362-370. 1985
- Diagnosis of Pseudo-Arylsulfatase A Deficiency with Electrophoretic Techniques. Pediatric Research. 18:1042-1045. 1984
- A specific ultrastructural stain for arylsulfatase A activity in human cultured fibroblasts.. Journal of Histochemistry and Cytochemistry. 32:617-624. 1984
- Biochemical variability of arylsulphatases‐A,‐B and‐C in cultured fibroblasts from patients with multiple sulphatase deficiency. Journal of Inherited Metabolic Disease. 6:167-172. 1983
- Pseudo arylsulfatase-A deficiency in healthy individuals: genetic and biochemical relationship to metachromatic leukodystrophy.. Proceedings of the National Academy of Sciences of the United States of America. 80:7323-7327. 1983
- Mucolipidosis II. The clinical, radiological and biochemical features in three cases. Clinical Genetics. 24:90-96. 1983
- Gene dosage effects in human diploid and tetraploid fibroblasts. Experimental Cell Research. 145:277-284. 1983
- Somatic cell hybridization studies on the genetic regulation and allelic mutations in metachromatic leukodystrophy. Human Genetics. 61:231-235. 1982
- Differential assay of arylsulfatase A and B activities: A sensitive method for cultured human cells. Analytical Biochemistry. 117:382-389. 1981
- Complementation of arylsulfatase A in somatic hybrids of metachromatic leukodystrophy and multiple sulfatase deficiency disorder fibroblasts.. Proceedings of the National Academy of Sciences of the United States of America. 77:6166-6170. 1980
- Corrigendum. Nature. 280:518-518. 1979
- Detection of arylsulfatase A activity after electrophoresis in polyacrylamide gels: Problems and solutions. Analytical Biochemistry. 97:36-42. 1979
- Non-selective isolation of human somatic cell hybrids by unit-gravity sedimentation. Nature. 278:168-170. 1979
- The use of fluorogenic substrates to locate rapidly enzyme activity in chromatographic fractions. Analytical Biochemistry. 88:327-331. 1978
- Characterization of intracisternal and membrane subfractions from sonically disrupted rough microsomal and Golgi-rich fractions of the rat liver. Experimental Cell Research. 112:187-197. 1978
- Biosynthesis of phosphatidylethanolamine from CDP-ethanolamine by the Golgi complex of rat liver in vitro. Cellular and Molecular Life Sciences. 33:1136-1137. 1977
- Incorporation in vivo of [32P]orthophosphate and [Me-3H]choline into rough microsomal, Golgi, and plasma membranes of rat liver. Biochemistry and Cell Biology. 55:876-885. 1977