Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity Academic Article uri icon

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abstract

  • Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.

authors

  • Bürkle, Alexander
  • Beneke, Sascha
  • Brabeck, Christine
  • Leake, Alan
  • Meyer, Ralph
  • Muiras, Marie-Laure
  • Pfeiffer, Ragen

publication date

  • October 2002