Journal article
Transforming growth factor β1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells
Abstract
Bone metastases are a common complication in prostate and breast cancer patients. It leads to extensive morbidity and eventually mortality. Matrix metalloproteinases (MMPs) are known to be involved in the metastatic process. MMP activity can be down-regulated by transforming growth factor β1 (TGF-β1), a growth-modulating factor, found in high concentrations in the bone. TGF-β1 acts through the TGF-β1 inhibitory element (TIE) element, a …
Authors
Duivenvoorden WCM; Hirte HW; Singh G
Journal
Clinical & Experimental Metastasis, Vol. 17, No. 1, pp. 33–42
Publisher
Springer Nature
Publication Date
February 1999
DOI
10.1023/a:1026404227624
ISSN
0262-0898