Nuclear Matrix Condensation and c-myc and c-fos Expression Are Specifically Altered in Cultured Rat Hepatocytes after Exposure to Cyproterone Acetate and Phenobarbital

Regenerative or hyperplastic growth promotes carcinogenesis and can be induced by many nongenotoxic carcinogens. The mitogenic potential of the rodent liver tumor promoters, cyproterone acetate and phenobarbital was investigated in primary rat hepatocyte cultures. Two premitotic markers were analyzed, the expression of two immediate-early genes (c-fos and c-myc) and the decrease in the nuclear quinacrine dihydrochloride fluorescence indicative …