Journal article
Cigarette Smoke Decreases Pulmonary Dendritic Cells and Impacts Antiviral Immune Responsiveness
Abstract
We investigated the impact of cigarette smoke exposure on respiratory immune defense mechanisms. Mice were exposed to two cigarettes daily, 5 d/wk, for 2-4 mo. Tobacco smoke decreased the number of dendritic cells (DCs) in the lung tissue. Furthermore, smoke exposure dramatically reduced the percentage of B7.1-expressing DCs. Because DCs are believed to be indispensable to the initiation of adaptive immune responses, we investigated the impact …
Authors
Robbins CS; Dawe DE; Goncharova SI; Pouladi MA; Drannik AG; Swirski FK; Cox G; Stämpfli MR
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 30, No. 2, pp. 202–211
Publisher
American Thoracic Society
Publication Date
2 2004
DOI
10.1165/rcmb.2003-0259oc
ISSN
1044-1549