Journal article
Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines
Abstract
There is a requirement for vaccines or vaccination strategies that confer better protection against TB than the current live attenuated Mycobacterium bovis Bacillus Calmette-Guerin (BCG) vaccine for use in cattle. Boosting with recombinant viral vectors expressing mycobacterial proteins, such as Ag85A, has shown a degree of promise as a strategy for improving on the protection afforded by BCG. Experiments in small animal models have indicated …
Authors
Dean G; Whelan A; Clifford D; Salguero FJ; Xing Z; Gilbert S; McShane H; Hewinson RG; Vordermeier M; Villarreal-Ramos B
Journal
Vaccine, Vol. 32, No. 11, pp. 1304–1310
Publisher
Elsevier
Publication Date
March 2014
DOI
10.1016/j.vaccine.2013.11.045
ISSN
0264-410X