Conference
Adenovirus Vectors for Cytokine Gene Expression
Abstract
Recombinant Adenovirus type 5 constructs containing IL-6 cDNA can be used to infect cells in vitro and obtain a high level of IL-6 expression and secretion into culture media. Furthermore, Ad5-IL-6 viruses can also be used to infect Balb/c mice or Sprague-Dawley rats and obtain a high level of IL-6 expression that is sustained over a period of 3-5 days. Intratracheal infection was accompanied by dramatic increases in virus-encoded IL-6 mRNA …
Authors
RICHARDS CD; BRACIAK T; XING Z; GRAHAM F; GAULDIE J
Volume
762
Pagination
pp. 282-293
Publisher
Wiley
Publication Date
7 1995
DOI
10.1111/j.1749-6632.1995.tb32333.x
Conference proceedings
Annals of the New York Academy of Sciences
Issue
1
ISSN
0077-8923