Chronic immune thrombocytopenic purpura in children: a survey of the canadian experience. Academic Article uri icon

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abstract

  • BACKGROUND: Immune thrombocytopenic purpura (ITP) in children is a common pediatric bleeding disorder with heterogeneous manifestations and a natural history that is not fully understood. To better understand the natural history of chronic ITP and detect response trends and outcomes of therapy, we conducted a 10-year retrospective survey of children from age 1 to 18 years with a diagnosis of chronic ITP. RESULTS: Data on 198 patients from 8 Canadian Pediatric Hematology/Oncology centers were analyzed. The majority of patients were female (58%), and were previously diagnosed with acute (primary) ITP (85%). The age at diagnosis of chronic ITP ranged from 1.1 to 17.2 years with a mean of 8.2+/-4.4 years. Ninety percent of patients received some form of treatment. Untreated patients had a higher mean platelet count at diagnosis of chronic ITP (P=0.009) despite similarities in mean age at first presentation and mean duration of follow-up. Thirty-four (17%) patients underwent splenectomy. Splenectomized patients tended to be significantly older, had a lower mean platelet count at diagnosis of chronic ITP, and had a longer duration of follow-up. CONCLUSIONS: The results from this study are consistent with published reports.

authors

  • Belletrutti, Mark
  • Ali, Kaiser
  • Barnard, Dorothy
  • Blanchette, Victor
  • Chan, Anthony
  • David, Michele
  • Luke, Brian
  • Price, Victoria
  • Ritchie, Bruce
  • Wu, John
  • Canadian Pediatric Chronic ITP Working Group
  • Canadian Pediatric Thrombosis and Hemostasis Network

publication date

  • February 2007