Journal article
Modification of Polyurethane Surface with an Antithrombin–Heparin Complex for Blood Contact: Influence of Molecular Weight of Polyethylene Oxide Used as a Linker/Spacer
Abstract
Polyurethane (PU) was modified using isocyanate chemistry to graft polyethylene oxide (PEO) of various molecular weights (range 300-4600). An antithrombin-heparin (ATH) covalent complex was subsequently attached to the free PEO chain ends, which had been functionalized with N-hydroxysuccinimide (NHS) groups. Surfaces were characterized by water contact angle and X-ray photoelectron spectroscopy (XPS) to confirm the modifications. Adsorption of …
Authors
Sask KN; Berry LR; Chan AKC; Brash JL
Journal
Langmuir, Vol. 28, No. 4, pp. 2099–2106
Publisher
American Chemical Society (ACS)
Publication Date
January 31, 2012
DOI
10.1021/la203821g
ISSN
0743-7463