Journal article
Electrophysiological characterization of voltage-dependent calcium currents and TRPV4 currents in human pulmonary fibroblasts
Abstract
We have presented indirect evidence of a key role for voltage-dependent Ca(2+) currents in TGFβ-induced synthetic function in human pulmonary fibroblast (HPF), as well as in bleomycin-induced pulmonary fibrosis in mice. Others, however, have provided indirect evidence for transient receptor potential vanilloid 4 (TRPV4) channels in both of those effects. Unfortunately, definitive electrophysiological descriptions of both currents in HPFs have …
Authors
Rahman M; Mukherjee S; Sheng W; Nilius B; Janssen LJ
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 310, No. 7, pp. l603–l614
Publisher
American Physiological Society
Publication Date
April 1, 2016
DOI
10.1152/ajplung.00426.2015
ISSN
1040-0605