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1976 and 2009 H1N1 Influenza Virus Vaccines Boost...
Journal article

1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans

Abstract

BACKGROUND: Infection with pandemic H1N1 influenza A viruses (IAVs) containing hemagglutinin (HA) proteins with globular heads that differ substantially from seasonal strains results in a boost in broadly cross-reactive antibodies that bind to the HA stalk. Boosting these antibodies has become an attractive strategy for creating a universal IAV vaccine. Therefore, it was essential to determine whether vaccines containing H1N1 viruses whose head …

Authors

Miller MS; Tsibane T; Krammer F; Hai R; Rahmat S; Basler CF; Palese P

Journal

The Journal of Infectious Diseases, Vol. 207, No. 1, pp. 98–105

Publisher

Oxford University Press (OUP)

Publication Date

January 1, 2013

DOI

10.1093/infdis/jis652

ISSN

0022-1899