Assignment by Deletion of Human Red Cell Acid Phosphatase Gene Locus to the Short Arm of Chromosome 2

DEVELOPMENT malformations associated with gross chromosomal deletions are well known in man. Those cases in which the extent of the deletion can be defined accurately by chromosome banding techniques should provide an opportunity for identifying some of the gene loci located within the deleted segment. But the positive assignment of a gene locus to a particular region in the human karyotype does not seem to have been achieved by this method. In several promising cases, the coincidence of a deletion and the familial segregation of an undetectable or “silent” allele has raised false hopes1.