Journal article
CRISPR/RNA Aptamer System Activated by an AND Logic Gate for Biomarker-Driven Theranostics
Abstract
The development of an engineered RNA device capable of detecting multiple biomarkers to evaluate pathological states and autonomously implement responsive therapies is urgently needed. Here, we report InCasApt, an integrated nano CRISPR Cas13a/RNA aptamer theranostic platform capable of achieving both biomarker detection and biomarker-driven therapy. Within this system, a Cas13a/crRNA complex, a hairpin reporter (HR), a dinitroaniline caged Ce6 …
Authors
Yang Q; Dong M-J; Xu J; Xing Y; Wang Y; Yang J; Meng X; Xie T; Li Y; Dong H
Journal
Journal of the American Chemical Society, Vol. 147, No. 1, pp. 169–180
Publisher
American Chemical Society (ACS)
Publication Date
January 8, 2025
DOI
10.1021/jacs.4c08719
ISSN
0002-7863