Journal article
Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways
Abstract
AIMS: The entry of lipoproteins from blood into the arterial wall is a rate-limiting step in atherosclerosis. It is controversial whether this happens by filtration or regulated transendothelial transport.Because sphingosine-1-phosphate (S1P) preserves the endothelial barrier, we investigated in vivo and in vitro, whether S1P and its cognate S1P-receptor 3 (S1P3) regulate the transendothelial transport of lipoproteins.
METHODS AND RESULTS: …
Authors
Velagapudi S; Wang D; Poti F; Feuerborn R; Robert J; Schlumpf E; Yalcinkaya M; Panteloglou G; Potapenko A; Simoni M
Journal
Cardiovascular Research, Vol. 120, No. 5, pp. 476–489
Publisher
Oxford University Press (OUP)
Publication Date
April 30, 2024
DOI
10.1093/cvr/cvad183
ISSN
0008-6363