Journal article
Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart
Abstract
Type 2 diabetes has a strong association with the development of cardiovascular disease, which is grouped as diabetic heart disease (DHD). DHD is associated with the progressive loss of cardiovascular cells through the alteration of molecular signalling pathways associated with cell death. In this study, we sought to determine whether diabetes induces dysregulation of miR-532 and if this is associated with accentuated apoptosis. RT-PCR analysis …
Authors
Chandrasekera DNK; Neale JPH; van Hout I; Rawal S; Coffey S; Jones GT; Bunton R; Sugunesegran R; Parry D; Davis P
Journal
Apoptosis, Vol. 25, No. 5-6, pp. 388–399
Publisher
Springer Nature
Publication Date
June 2020
DOI
10.1007/s10495-020-01609-1
ISSN
1360-8185
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overAnimalsAntagomirsApoptosisApoptosis Regulatory ProteinsCaspase 3Caspase 7Cell LineCholesterol, HDLCholesterol, LDLDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FemaleGene Expression RegulationGlucoseGlycated HemoglobinHeart AtriaHumansMaleMicroRNAsMiddle AgedMuscle ProteinsMyocardiumMyocytes, CardiacSignal TransductionTriglycerides