Eicosapentaenoic acid changes muscle transcriptome and intervenes in aging-related fiber type transition in male mice Journal Articles uri icon

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  • This study demonstrated that the early phenotype of skeletal muscle in aging male mice is characterized by muscle weakness with fast-to-slow fiber type transition, which could be ameliorated by feeding with EPA-enriched diet. EPA induced metabolic changes such as an increase in systemic insulin sensitivity and altered muscle transcriptome in the aging mice. These changes may be related to the fiber type transition and influence muscle quality.


  • Yamazaki, Hiroki
  • Nishimura, Mayu
  • Uehara, Masaaki
  • Kuribara-Souta, Akiko
  • Yamamoto, Motohisa
  • Yoshikawa, Noritada
  • Morohashi, Ken-Ichirou
  • Tanaka, Hirotoshi

publication date

  • February 1, 2021