Journal article
Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression
Abstract
BACKGROUND: Antidepressants are used to treat acute depression in patients with bipolar I disorder, but their effect as maintenance treatment after the remission of depression has not been well studied.
METHODS: We conducted a multisite, double-blind, randomized, placebo-controlled trial of maintenance of treatment with adjunctive escitalopram or bupropion XL as compared with discontinuation of antidepressant therapy in patients with bipolar I …
Authors
Yatham LN; Arumugham SS; Kesavan M; Ramachandran K; Murthy NS; Saraf G; Ouyang Y; Bond DJ; Schaffer A; Ravindran A
Journal
New England Journal of Medicine, Vol. 389, No. 5, pp. 430–440
Publisher
Massachusetts Medical Society
Publication Date
August 3, 2023
DOI
10.1056/nejmoa2300184
ISSN
0028-4793