Journal article
Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens
Abstract
Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. Additionally, MAIT cells sense and respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted in immunization strategies against viral pathogens is unclear. We addressed this question in multiple wild-type and genetically altered but clinically …
Authors
Rashu R; Ninkov M; Wardell CM; Benoit JM; Wang NI; Meilleur CE; D’Agostino MR; Zhang A; Feng E; Saeedian N
Journal
PLOS Pathogens, Vol. 19, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.ppat.1011485
ISSN
1553-7366