selected scholarly activity
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academic article
- Ex vivo-expanded NK cells from blood and ascites of ovarian cancer patients are cytotoxic against autologous primary ovarian cancer cells.. Cancer Immunology and Immunotherapy. 67:575-587. 2018
- Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice.. Scientific Reports. 7:15263. 2017
- Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.. Scientific Reports. 7:12083. 2017
- IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation.. Molecular Immunology. 88:138-147. 2017
- Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.. Journal of Infectious Diseases. 216:135-145. 2017
- Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.. Breast Cancer Research. 19:76. 2017
- Type I interferon signalling is not required for the induction of endotoxin tolerance.. Cytokine. 95:7-11. 2017
- Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection.. Journal of Experimental Medicine. 214:1153-1167. 2017
- NK cells require antigen-specific memory CD4+T cells to mediate superior effector functions during HSV-2 recall responses in vitro.. Journal of Leukocyte Biology. 101:1045-1052. 2017
- Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells.. Journal of Innate Immunity. 9:511-525. 2017
- M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.. Journal of Leukocyte Biology. 101:285-295. 2017
- The Application of Humanized Mouse Models for the Study of Human Exclusive Viruses.. Methods in Molecular Biology. 1656:1-56. 2017
- Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.. Proceedings of the National Academy of Sciences of the United States of America. 113:11931-11936. 2016
- The breast tumor microenvironment alters the phenotype and function of natural killer cells.. Cellular and Molecular Immunology. 13:628-639. 2016
- Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge.. Vaccine. 34:3979-3985. 2016
- Analysis of the effects of microbiome-related confounding factors on the reproducibility of the volatolomic test.. Journal of Breath Research. 10:037101. 2016
- Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice.. BMC Immunology. 17:18. 2016
- Innate immunosurveillance: the next frontier in the cancer immunotherapy toolbox. TRANSLATIONAL CANCER RESEARCH. 5:S66-S70. 2016
- S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.. Nature Immunology. 17:514-522. 2016
- Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity.. Innate Immunity. 21:626-634. 2015
- Vitamin D3 modulates the function of chicken macrophages.. Research in Veterinary Science. 100:45-51. 2015
- Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.. BMC Cancer. 15:293. 2015
- 24(th) Annual Canadian Conference on HIV/AIDS Research/24(e) Congrès Annuel Canadien de Recherche sur le VIH/sida CAHR Committees / Comités de l'ACRV.. Canadian Journal of Infectious Diseases Canadian Journal of Infectious Diseases and Medical Microbiology. 26 Suppl B:4B-5B. 2015
- Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.. EMBO Molecular Medicine. 7:259-274. 2015
- Novel function of Oncostatin M as a potent tumour-promoting agent in lung.. International Journal of Cancer. 136:831-843. 2015
- Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma.. Mol Ther Oncolytics. 2:15004. 2015
- The absence or overexpression of IL-15 drastically alters breast cancer metastasis via effects on NK cells, CD4 T cells, and macrophages.. Journal of Immunology. 193:6184-6191. 2014
- T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.. Mucosal Immunology. 7:1395-1404. 2014
- Novel roles of cytoplasmic ICP0: proteasome-independent functions of the RING finger are required to block interferon-stimulated gene production but not to promote viral replication.. Journal of Virology. 88:8091-8101. 2014
- Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells.. Mucosal Immunology. 7:670-683. 2014
- Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection.. European Journal of Immunology. 44:1375-1386. 2014
- Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.. PLoS One. 9:e114799. 2014
- Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type.. Journal of Leukocyte Biology. 94:1025-1036. 2013
- HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.. Journal of Immunology. 191:4246-4258. 2013
- Type I interferon regulation of natural killer cell function in primary and secondary infections.. Expert Review of Vaccines. 12:875-884. 2013
- Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells (vol 90, pg 1047, 2012). Journal of Molecular Medicine Clinical Investigator. 91:903-904. 2013
- Interleukin-15 is required for maximal lipopolysaccharide-induced abortion.. Journal of Leukocyte Biology. 93:905-912. 2013
- Hypertension management in the high cardiovascular risk population.. International Journal of Hypertension. 2013:382802. 2013
- Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells.. Mediators of Inflammation. 2013:317503. 2013
- The influence of macrophages and the tumor microenvironment on natural killer cells.. Current Molecular Medicine. 13:68-79. 2013
- The Influence of Macrophages and the Tumor Microenvironment on Natural Killer Cells. Current Molecular Medicine. 13:68-79. 2012
- Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.. Journal of Molecular Medicine Clinical Investigator. 90:1047-1057. 2012
- Critical role of natural killer cells in lung immunopathology during influenza infection in mice.. Journal of Infectious Diseases. 206:167-177. 2012
- IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.. Journal of Immunology. 188:4149-4157. 2012
- Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity.. Cancer Gene Therapy. 19:238-246. 2012
- Herpes simplex virus-2 in the genital mucosa: insights into the mucosal host response and vaccine development.. Current Opinion in Infectious Diseases. 25:92-99. 2012
- Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice.. Diabetes, Obesity and Metabolism. 14:190-193. 2012
- Genital HSV-2 infection induces short-term NK cell memory.. PLoS One. 7:e32821. 2012
- Immunity to ocular and genital herpes simplex viruses infections.. Clinical and Developmental Immunology. 2012:732546. 2012
- Interleukin-15 treatment induces weight loss independent of lymphocytes.. PLoS One. 7:e39553. 2012
- The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts.. PLoS One. 7:e31688. 2012
- FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice.. Antiviral Research. 92:346-355. 2011
- A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection.. Immunology and Cell Biology. 89:663-669. 2011
- Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner.. Journal of Infectious Diseases. 204:299-308. 2011
- Humanized mice for Salmonella typhi infection: new tools for an old problem.. Virulence. 2:248-252. 2011
- Stimulating natural killer cells to protect against cancer: recent developments.. Expert Review of Clinical Immunology. 7:367-382. 2011
- IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells.. Cancer Research. 71:2497-2506. 2011
- Induction of innate immune responses in the female genital tract: friend or foe of HIV-1 infection?. American Journal of Reproductive Immunology and Microbiology American Journal of Reproductive Immunology. 65:344-351. 2011
- Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa.. Journal of Reproductive Immunology. 88:210-218. 2011
- CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice.. Cellular Immunology. 266:180-186. 2011
- Characterization and IL-15 dependence of NK cells in humanized mice.. Immunobiology. 216:218-224. 2011
- Humanized mice are susceptible to Salmonella typhi infection.. Cellular and Molecular Immunology. 8:83-87. 2011
- NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection.. Cellular Immunology. 269:29-37. 2011
- Effective control of viral infections by the adaptive immune system requires assistance from innate immunity.. Expert Review of Vaccines. 9:1143-1147. 2010
- IL-15 has innate anti-tumor activity independent of NK and CD8 T cells.. Journal of Leukocyte Biology. 88:529-536. 2010
- Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes.. Obesity Research Obesity. 18:1601-1607. 2010
- FimH can directly activate human and murine natural killer cells via TLR4.. Molecular Therapy. 18:1379-1388. 2010
- Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung.. Journal of Immunology. 184:2048-2056. 2010
- Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.. PLoS One. 4:e8379. 2009
- Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model.. Journal of Virology. 83:10664-10676. 2009
- Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs.. Molecular Immunology. 46:3108-3116. 2009
- Interferon gamma in successful pregnancies.. Biology of Reproduction. 80:848-859. 2009
- Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production.. Molecular Immunology. 46:821-829. 2009
- Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women.. Antiviral Research. 81:103-112. 2009
- Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues.. Infection and Immunity. 77:214-222. 2009
- Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-gamma.. Cellular Immunology. 258:59-64. 2009
- Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2.. Journal of Virology. 83:918-926. 2009
- FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling.. PLoS Pathogens. 4:e1000233. 2008
- Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand.. Journal of Immunology. 181:6702-6706. 2008
- NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung.. Journal of Immunology. 180:5558-5568. 2008
- Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.. Journal of Leukocyte Biology. 83:774-784. 2008
- The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection.. American Journal of Reproductive Immunology and Microbiology American Journal of Reproductive Immunology. 59:35-43. 2008
- Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection.. Biology of Reproduction. 77:1049-1059. 2007
- Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection.. Journal of Immunology. 179:4015-4026. 2007
- Adaptive immune responses fail to provide protection against genital HSV-2 infection in the absence of IL-15.. European Journal of Immunology. 37:2529-2538. 2007
- The role of IL-15 signaling in the induction of innate antiviral responses. Current Signal Transduction Therapy. 2:180-185. 2007
- Toll-like receptors, natural killer cells and innate immunity.. Advances in Experimental Medicine and Biology. 598:1-11. 2007
- Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production.. Journal of Virology. 80:9943-9950. 2006
- Protection against Listeria monocytogenes by ODN containing CpG motifs in BALB/c and C57BL/6 mice. Journal of Applied Animal Research. 29:145-147. 2006
- The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity.. Cellular Immunology. 241:102-112. 2006
- Hypertension in the elderly.. Primary Care - Clinics in Office Practice. 32:723-753. 2005
- Interferon-gamma alters the phagocytic activity of the mouse trophoblast.. Reproductive Biology and Endocrinology. 3:34. 2005
- NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection.. Journal of Virology. 79:4470-4478. 2005
- Herpesviruses and the innate immune response.. Viral Immunology. 18:267-281. 2005
- Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA.. Journal of Infectious Diseases. 190:1841-1849. 2004
- Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge.. Journal of Medical Virology. 71:561-568. 2003
- Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy.. Journal of Immunology. 171:2937-2944. 2003
- Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection.. Journal of Virology. 77:10168-10171. 2003
- Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2.. Journal of Virology. 77:9845-9851. 2003
- Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2.. Journal of Virology. 77:8948-8956. 2003
- Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus.. Journal of Reproductive Immunology. 59:175-191. 2003
- Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling.. Reproduction Journal of Reproduction and Fertility Reviews of Reproduction. 126:149-160. 2003
- Progesterone increases susceptibility and decreases immune responses to genital herpes infection.. Journal of Virology. 77:4558-4565. 2003
- Decidual natural killer cells: key regulators of placental development (a review).. Journal of Reproductive Immunology. 57:151-168. 2002
- Toll-like receptor 9, CpG DNA and innate immunity.. Current Molecular Medicine. 2:545-556. 2002
- Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy.. Seminars in Immunology. 13:235-241. 2001
- Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy.. Journal of Experimental Medicine. 192:259-270. 2000
- Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy--a review.. Placenta. 21 Suppl A:S77-S80. 2000
- Can murine uterine natural killer cells give insights into the pathogenesis of preeclampsia?. Journal of the Society for Gynecologic Investigation Reproductive Sciences. 7:12-20. 2000
- Interferon-gamma contributes to the normalcy of murine pregnancy.. Biology of Reproduction. 61:493-502. 1999
- A preliminary study on the usefulness of huIL-8 in cervical relaxation of the ewe for artificial insemination and for embryo transfer.. Theriogenology. 52:271-287. 1999
- Outbreak of tetanus in lambs.. Veterinary Record. 142:518-519. 1998
- Major depression and external stressors: the Lebanon Wars.. European Archives of Psychiatry and Clinical Neuroscience. 248:225-230. 1998
- Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.. Journal of Reproductive Immunology. 35:111-133. 1997
- Self-care under war conditions. The case of Beirut, Lebanon.. Medical Care. 25:904-912. 1987
- Acute toxicity of benzene inhalation to hemopoietic precursor cells.. Toxicology and Applied Pharmacology. 40:49-57. 1977
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conference paper
- Human airway smooth muscle cell responses to TLR-ligands are enhanced by oncostatin M. Cytokine. 268-268. 2013