Journal article
Constitutive expression of interleukin-27 diminishes proinflammatory cytokine production without impairing effector function of engineered T cells
Abstract
Immunomodulatory cytokines can alter the tumor microenvironment and promote tumor eradication. Interleukin (IL)-27 is a pleiotropic cytokine that has potential to augment anti-tumor immunity while also facilitating anti-myeloma activity. We engineered human T cells to express a recombinant single-chain (sc)IL-27 and a synthetic antigen receptor targeting the myeloma antigen, B-cell maturation antigen, and evaluated the anti-tumor function of T …
Authors
Afsahi A; Burchett R; Baker CL; Moore AE; Bramson JL
Journal
Cytotherapy, Vol. 25, No. 9, pp. 913–919
Publisher
Elsevier
Publication Date
September 2023
DOI
10.1016/j.jcyt.2023.05.004
ISSN
1465-3249