A systematic review and meta-analysis of sample size methodology for traumatic hemorrhage trials

BACKGROUND: Trauma hemorrhage remains the most common cause of preventable mortality in trauma. To guide clinical practice, RCTs provide high-quality evidence to inform clinical decision making. The clinical relevance and inferences made by RCTs are dependent on assumptions made during sample size calculation. METHODS: To describe the quality of methodology for sample size determination, we conducted a systemic review RCTs evaluating …