This study examined the performance of the upper limbs during responses to previously cued and un-cued locations. Participants made unimanual and bimanual responses under homologous and non-homologous muscular control, within a cuetarget (Experiment 1;
n= 10), and a target-target (Experiment 2; n= 10) aiming protocol. The inhibition of return (IOR) to a target location was expected to increase with (a) an increase in the organization of the movement response required, and (b) the decrease in the muscular coupling under which the bimanual movement was performed. IOR was observed in both experiments when participants completed their movements in either the unimanual or homologous conditions, but not in the non-homologous condition. In addition, reaction times were significantly shorter when a movement preceded the response than when no manual response was made to the initial visual cue. The results indicate that common processing delays in response to exogenously cued targets are dependent on the muscular control of those responses. Thus, this study provides evidence that IOR is moderated by the muscular control under which the bimanual movement was performed indicating an influential involvement of the motor system in both the movement planning and movement response to multiple target stimuli.