Journal article
Quantitative fluorescence imaging of point-like sources in small animals
Abstract
A planar imaging approach is described for the in vivo quantitative reconstruction of fluorescent point sources in small animals. The method uses the diffusion approximation as a forward model of light propagation from a point source in a homogeneous tissue to find source depth and strength. The tissue optical properties obtained from video reflectometry measurements were used to compensate for the effects of tissue heterogeneity. The method …
Authors
Comsa DC; Farrell TJ; Patterson MS
Journal
Physics in Medicine and Biology, Vol. 53, No. 20, pp. 5797–5814
Publisher
IOP Publishing
Publication Date
October 21, 2008
DOI
10.1088/0031-9155/53/20/016
ISSN
0031-9155